The gastrointestinal tract is an asymmetrically patterned organ system. The signals which initiate left‐right asymmetry in the developing embryo have been extensively studied, but the downstream steps required to confer asymmetric morphogenesis on the gut organ primordia are less well understood. In this paper we outline key findings on the tissue mechanics underlying gut asymmetry, across a range of species, and use these to synthesise a conserved model for asymmetric gut morphogenesis. We also discuss the importance of correct establishment of (...) left‐right asymmetry for gut development and the consequences of perturbations in this process. (shrink)

How, and how well, do people switch between exploration and exploitation to search for and accumulate resources? We study the decision processes underlying such exploration/exploitation trade‐offs using a novel card selection task that captures the common situation of searching among multiple resources (e.g., jobs) that can be exploited without depleting. With experience, participants learn to switch appropriately between exploration and exploitation and approach optimal performance. We model participants' behavior on this task with random, threshold, and sampling strategies, and find that (...) a linear decreasing threshold rule best fits participants' results. Further evidence that participants use decreasing threshold‐based strategies comes from reaction time differences between exploration and exploitation; however, participants themselves report non‐decreasing thresholds. Decreasing threshold strategies that “front‐load” exploration and switch quickly to exploitation are particularly effective in resource accumulation tasks, in contrast to optimal stopping problems like the Secretary Problem requiring longer exploration. (shrink)

Books reviewed:John Barton, Joel and Obadiah: A Commentary John P. Meier, A Marginal Jew, Volume III: Companions and CompetitorsWilliam E. Arnal, Jesus and the Village Scribes: Galilean Conflicts and the Setting of QRichard A. Horsley, Hearing the Whole Story: The Politics of Plot in Mark's GospelMaurice Casey, Aramaic Sources of Mark's GospelPhilip Jenkins, Hidden Gospels: How the Search for Jesus Lost its WayChristopher M. Tuckett, Christology and the New Testament: Jesus and His Earliest FollowersMarkus Bockmuehl, The Cambridge Companion to JesusShelly (...) Matthews, First Converts: Rich Pagan Women and the Rhetoric of Mission in Early Judaism and ChristianityStephen J. Davis, The Cult of Saint Thecla: A Tradition of Women's Piety in Late AntiquityJ. Nimmo Smith, A Christian's Guide to Greek Culture. The Pseudo‐Nonnus Commentaries on Sermons 4, 5, 39 and 43 by Gregory of Nazianzus: Introduction, Translation and Notes.David Thomas, Early Moslem Polemic Against Christianity: Abu Isa al‐Warraq's ‘Against the Incarnation’Thomas O'Loughlin, Celtic Theology: Humanity, World and God in Early Irish WritingsCaroline M. Baron and Jenny Stratford, The Church and Learning in Later Medieval Society: Essays in Honour of R. B. Dobson Owen Chadwick, The Early Reformation on the Continent Benson Bobrick, The Making of the English BiblePeter Marhall and Alec Ryrie, The Beginnings of English ProtestantismRobert Tittler, The Reformation and the Towns in England. Politics and Political Culture, c. 1540–1640Peter Marshall, Beliefs and the Dead in Reformation EnglandNicholas Tyacke, Aspects of English Protestantism, c.1530–1700John Coffey, Persecution and Toleration in Protestant England, 1558–1689William Gibson, The Church of England 1688–1832: Unity and AccordWarwick Gould and Marjorie Reeves, Joachim of Fiore and the Myth of the Eternal Evangel in the Nineteenth and Twentieth CenturiesJames M. Byrne, God: Thoughts in an Age of Uncertainty Michael Palmer, The Question of God: An Introduction and SourcebookMichel René Barnes, The Power of God: ΔYNAMIΣ in Gregory of Nyssa's Trinitarian TheologyThomas Aquinas, Disputed Questions on VirtueStanley M. Hauerwas, Wilderness Wanderings: Probing Twentieth‐Century Theology and PhilosophyDavid Toole, Waiting for Godot in Sarajevo: Theological Reflections on Nihilism, Tragedy, and ApocalypseJohn Sullivan, Catholic Education: Distinctive and InclusiveGeorge Dennis O'Brien, The Idea of a Catholic UniversityGunnar Skirbekk and Nils Gilje, A History of Western ThoughtEllen Wagner, Essays on Plato's PsychologyAnthony Kenny, Aquinas on BeingJame Daly, Deals and Ideals: Two Concepts of EnlightenmentManfred Kuehn, Kant: A BiographyP. Travis Kroeker and Bruce K. Ward, Remembering the End: Dostoevsky as Prophet to ModernityStephen Mulhall, Inheritance and Originality: Wittgenstein, Heidegger, KierkegaardDavid Braybrooke, Natural Law ModernizedMaría Pía Lara, Rethinking EvilW. W. Meisner, Freud and PsychoanalysisJennifer Jackson, Truth, Trust and MedicineJeremy Sugarman and Daniel P. Sulmasy, Methods in Medical EthicsH. Tristram Engelhardt, Jr. and Mark J. Cherry, Allocating Scarce Medical Resources: Roman Catholic PerspectivesMaura A. Ryan, The Ethics and Economics of Assisted Reproduction: The Cost of LongingMichael Walsh, Dictionary of Christian Biography. (shrink)

This article argues that by using theories of the spatial to understand how situated materiality (i.e., place) and contestations of identity matter when conceiving global and curricular space, educators may interrupt and rearticulate practices and systems of oppression. By focusing on globalization writ large, there is danger of leaving important concerns of the local unattended, and thereby failing to see how processes of globalization exacerbate problematic and oft-hidden curricular issues. Such diversions typify the most insidious quality of the current form (...) of globalization; that is: an articulation of ubiquitous, uniform, and systemically oppressive social scripts. Through the contestation of such scripts, this article focuses on the achievement of better spaces when gender and race are involved. We offer a discussion of curriculum where students write about and argue against the dominant representations of their lives in Washington, DC. Concluding meditations stress that a new conceptual frame is needed in everyday curriculum theorizing, one that enables a reconstruction of curriculum theorists' positionalities with regard to our support, or rerouting, of the scripts that enable globalized systems of oppression and occlusion. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:176 BOOK REVIEWS tianity came into being. To take one example: God's involvement with and reaction to genuine novelties introduced into the world as a result of the initiatives of human freedom, rightly renders suspect the conception of God as immutable. But what immutability really claimed was not anything like inertia or unconcern, but only that God was not mutable in any of the ways characteristic of finite realities (...) striving to transcend their limitations. Immutability was predicated as a property of deity whose essence was Pure Actuality-the consummation of all mutation. What this meant to preclude from God was only change that amounted to some sort of further perfecting of his intrinsic being-leaving the way clear for the possibility at least of relational change vis-a-vis a world of creatures. There is no reason why contemporary experiences of God's saving activity in Christ must be articulated only in the conceptual and linguistic categories of the past. But seemingly there ought to be some means of showing that such newer articulations do not repudiate truths achieved in the past and handed on in authentic living tradition. The Catholic University of America Washington, D.C. WILLIAM J. HILL, 0.P. The Church: Communion, Sacrament, Communication. By ROBERT KRESS. New York: Paulist Press, 1985. Pp. iv + 217. $9.95. One of the results of the recent synod is certain to be more attention to deepening our understanding of the church as communion. Robert Kress's fine volume cannot help but be a useful contribution to that discussion. As he succinctly states, "the Church is the communion of believers who exist as the sacrament of Christ, who is the sacrament of God, who is the communion of Father, Son, and Holy Spirit" (p. 59). For Kress any ecclesiology that does not root the church in the triune, perichoretic (a favored word) life of God is a radically truncated one. As a theandric (another favored word) reality, the Church must mirror its ground or source. If that ground is a dynamic, joyous unity-in-diversity, this should be reflected in the life and structures of the ecclesial community. Such is the context in which the author reflects on a variety of themes that are reflective of the post-Vatican II agenda: the relationship among local, regional, and universal churches; the understanding of the church as sacrament; the tension between holiness and office; the meaning of leadership in a community best understood as a perichoretic communion of gifted members. To each of these topics Kress brings a grasp of the BOOK REVIEWS 177 tradition, a wide acquaintance with the relevant theological literature, and a willingness to make provocative judgments ("yes" to the ordination of women; " no " to the new egalitarianism-a church conceived without administrative, pastoral authority.) Kress particularly cherishes the church as "the memory and tradition of Christ." His commitment to this tradition has both rooted him and freed him. He draws knowledgeably on Aquinas and Augustine, Rahner and Heidegger, von Balthasar and the Shepherd of Hermas. Lawrence Cunningham is correct: this book is radically conservative. There is one area where I felt that there was a certain lack. Kress's treatment of the church as sacrament and of the seven sacraments contained much that was valuable: his stress on the sacramentality of ecclesial life as such, his historical analysis of "sacrament", his phenomenolog·y of the nature of Christian worship. Yet all of this seemed strangely abstracted from the liturgical praxis of the Christian community. This lack is especially visible in his admittedly tentative salvation-historical correlation of the sacraments with our sharing in the religious experience of Jesus (pp. 147-148). To make that correlation, especially in the case of Baptism, Confirmation, and Eucharist, without an exp1icit reference to the initiatory, communal dimension of these sacraments is certainly problematic. I would like to make a final comment, not on the substance of the book, but on its editing and proofing. There are a number of errors, the most obvious of which is the elimination of the umlaut from Heribert Miihlen's name. (There is a curious inconsistency, too, in the use of the umlaut. It is used in... (shrink)

If we peruse the Chuang Tzu (Zhuangzi) and the Nietzschean corpus, we will find numerous examples of evaluative statements. And yet, both Chuang Tzu and Nietzsche are well known for their critique of conventional value distinctions. Time and again they argue that our conventional value distinctions are invalid and sometimes even harmful. Are these two philosophers justified in making what appear to be self-negating claims? This essay offers a line of argument to justify their employment of evaluative language while at (...) the same time disclaiming its validity. My essential argument is that there are two levels of consciousness in both of these philosophers and that evaluative language is transcended at one of these levels but still possesses limited validity at the other. I assume, I believe correctly, that the purpose of philosophy for both philosophers is self-transformation. Given this functional direction of philosophizing, I divide the types of statements I will analyze into three standpoints: (1) “evaluative standpoint,” or statements which I take to be primarily evaluative in nature. “Class i” refers to the evaluative standpoint which is the standpoint not yet transcended and to be transcended; (2) “transevaluative standpoint”, or statements which I take to be primarily transevaluative in nature. “Class ii” refers to the transevaluative standpoint which is the standpoint to be achieved; (3) “transevaluative resultant values,” or statements which are primarily statements of the resultant value which are the product of a value free standpoint. “Class iii” refers to the resultant concrete values which are the product of following the transevaluative standpoint. My analyses lead to the conclusion that evaluative language is employed in its appropriate level of consciousness and transcended in the other level. In short, I propose that Chuang Tzu and Nietzsche can have their cake, and eat it, too. (shrink)

ABSTRACT Theories of the influence of technology on modern Western society have failed to take into account the important role played by a widespread pattern of sociotechnical practice. The pattern in question involves the interplay of technology, rights, and numbers. This paper argues that in the context of an ever more potent technological arsenal and an ever increasing number of individuals who have access to its elements and believe themselves entitled to use them in maximalist ways, adherence to the traditional (...) notion of individual human rights is anachronistic and increasingly problematic for the quality of life in contemporary society. To combat this situation, I criticise the idea of human rights as timelessly valid and offer a contextualised account of these constructs, one able to take on board the implications of their maximalist exercise in a populous technological society. I conclude by illustrating the struggles being waged over the adaptation of human rights to techno‐demographic reality in two areas of contemporary Western society: urban planning and medicine. (shrink)

The EEG and MEG studies cited in the target article found reduced gamma band power following pseudowords in comparison with words. Pulvermüller interprets this power difference in terms of reverberating lexical cell assemblies. An alternative interpretation in terms of latency jitter in the gamma band following pseudowords is proposed that does not appeal to lexical cell assemblies.

abstract ‘Time is money’, Benjamin Franklin's ‘Poor Richard’ tells us. But instead of converting time expenditures into monetary equivalents, it makes more sense in many cases to convert money into temporal equivalents. The difficulty in putting a monetary value on time in unpaid household labour, when adjusting the National Accounts, points to the problems of the first approach. The advantages of the latter approach are illustrated by the Swedish system of specifying criminal fines in terms of the number of days (...) the offender would have to work to pay them off. (shrink)

It has been demonstrated that death certificates do not accurately record the actual cause of death in up to one-fourth of cases, as determined from subsequent autopsy findings. The purpose of this study was to explore the use of natural language autopsy data bases as an automated quality assurance mechanism. We translated the account of the major process leading to death, or the primary diagnosis, from all 45,564 narrative autopsy reports obtained at The Johns Hopkins Hospital between May 28, 1889, (...) and June 30, 1987, into the hierarchical system of Medical Subject Heading (MeSH) titles. We obtained a total of 125,772 MeSH title translations, 1,563 of them distinct (average 2.8 per case), ranging in frequency from 6,029 occurrences of LUNG to 1 occurrence apiece of 357 MeSH titles. The natural-language-to-MeSH translations showed expected trends over the past century: fewer infectious diseases; more cardiovascular and neoplastic disease among adults; and more respiratory diseases and congenital malformations in the pediatric age group. The greater availability of autopsy documents in electronic form should increase the value of this resource for quality assurance. (shrink)

This volume presents the most recent research on Title I federal compensatory education programs. Over the past three decades, Title I of the Elementary and Secondary Education Act has served as the cornerstone of the federal commitment to equality of opportunity. It is the federal government's single largest investment in America's schools. As Title I begins a new century, this book documents the program's history and points to the potential for its future, building on 35 years of research, development, and (...) practical experience. The research and analysis it provides fills a void for systematic information that can help inform Title I education policies and practices. _Title I: Compensatory Education at the Crossroads_ is essential reading for educational researchers and students working in the areas of social stratification and equity-minded policies, programs, and practices. It will serve well as a text for graduate courses on these topics in education, as well as in public policy, sociology, and psychology. Educational policymakers and administrators at the federal, state, and local levels who are concerned with Title I and programs for students placed at risk will find it an important resource in crafting policies and programs for this population of students. (shrink)

In eukaryotes, folate metabolism is compartmentalized between the cytoplasm and organelles. The folate pathways of mitochondria are adapted to serve the metabolism of the organism. In yeast, mitochondria support cytoplasmic purine synthesis through the generation of formate. This pathway is important but not essential for survival, consistent with the flexibility of yeast metabolism. In plants, the mitochondrial pathways support photorespiration by generating serine from glycine. This pathway is essential under photosynthetic conditions and the enzyme expression varies with photosynthetic activity. In (...) mammals, the expression of the mitochondrial enzymes varies in tissues and during development. In embryos, mitochondria supply formate and glycine for purine synthesis, a process essential for survival; in adult tissues, flux through mitochondria can favor serine production. The differences in the folate pathways of mitochondria depending on species, tissues and developmental stages, profoundly alter the nature of their metabolic contribution. BioEssays 28: 595–605, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Ancient moral philosophers, especially Aristotle and his followers, typically shared the assumption that ethics is primarily concerned with how to achieve the final end for human beings, a life of “happiness” or “human flourishing.” This final end was not a subjective condition, such as contentment or the satisfaction of our preferences, but a life that could be objectively determined to be appropriate to our nature as human beings. Character traits were treated as moral virtues because they contributed well toward this (...) ideal life, either as means to it or as constitutive aspects of it. Traits that tended to prevent a “happy” life were considered vices, even if they contributed to a life that was pleasant and what a person most wanted. The idea of “happiness” was central, then, in philosophical efforts to specify what we ought to do, what sort of persons we should try to become, and what sort of life a wise person would hope for. (shrink)

What, if anything, are we morally required to do on behalf of others besides respecting their rights? And why is such regard for others a reasonable moral requirement? These two questions have long been major concerns of ethical theory, but the answers that philosophers give tend to vary with their beliefs about human nature. More specifically, their answers typically depend on the position they take on a third-question: To what extent, if any, is it possible for us to act altruistically?

Philosophers have debated for millennia about whether moral requirements are always rational to follow. The background for these debates is often what I shall call “the self-interest model.” The guiding assumption here is that the basic demand of reason, to each person, is that one must, above all, advance one's self-interest. Alternatively, debate may be framed by a related, but significantly different, assumption: the idea that the basic rational requirement is to develop and pursue a set of personal ends in (...) an informed, efficient, and coherent way, whether one's choice of ends is based on self-interested desires or not. For brevity I refer to this as “the coherence-and-efficiency model.” Advocates of both models tend to think that, while it is sufficiently clear in principle what the rational thing to do is, what remains in doubt is whether it is always rational to be moral. They typically assume that morality is concerned, entirely or primarily, with our relations to others, especially with obligations that appear to require some sacrifice or compromise with the pursuit of self-interest. (shrink)

Is Kantian Ethics guilty of utopian thinking? First, potentially good and bad uses of utopian ideals are distinguished, then an apparent path is traced from Rousseau’s unworkable political ideal to Kant’s ethical ideal. Three versions of Kant’s Categorical Imperative are examined briefly for the ways that they may raise the suspicion that they manifest or encourage bad utopian thinking. In each case Kantians have available responses to counter the suspicion, but special attention is directed to the version that says “Act (...) on the maxims of a universally law–giving member of a kingdom of ends.” Interpretations vary, but here primary focus is on one contemporary reconstruction and development of this central idea. Several objections suggest that this idea encourages bad utopian thinking are briefly addressed: that we cannot count on everyone to follow ideal rules, that even conscientious people disagree in their moral judgments, and that theories that allow exceptions to familiar moral rules create a “slippery slope” to moral chaos. (shrink)

Este artigo compara e contrapõe a abordagem naturalista pragmatista para a peculiaridade da linguagem, exemplificada, principalmente, mas, não exclusivamente, por John Dewey, com a extensa abordagem de Charles Taylor em seu O animal linguístico. Taylor, inspirado pelas obras de Hamann, Herder, e Humboldt, conta com recursos filosóficos e conceituais diferentes para o delineamento do que ele denomina de ‘a forma’ da capacidade linguística humana. Porém, Dewey e Taylor chegam a posições que se sobrepõem sem se identificar: a linguagem é a (...) característica definidora constitutiva dos seres humanos. Seres humanos são definidos pelo surgimento da ‘como’ consciência, uma ‘ruptura’ em nossa imersão imediata no mundo, e, como Peirce e Dewey mostraram de maneira tão lúcida, um reflexivo estar consciente do uso de signos e sistemas de signos de todos os tipos. Esses sistemas potencializam e transformam nosso acesso ao mundo e a nós mesmos. Eles não apenas rotulam um mudo já existente. Eles criam âmbitos de significados e valores que não surgiram sem eles. A distinção crucial de Taylor entre os modelos designativo e constitutivo da linguagem é apoiada plenamente pela consideração pragmatista da linguagem, a qual Taylor não declara. Essa distinção mostrará ser de importância especial para Dewey e Taylor na criação de paisagens existencialmente vitais de significado incorporados nas autodescrições e nas práticas delicadas das artes de auto-reflexão. Tanto Dewey quanto Taylor mostram que assim como as texturas abertas da experiência crescem por suas extremidades, assim a própria linguagem possui sua própria “extremidade” e nos aponta para os domínios “liminares” que sustentam o limiar do sentido para além do totalmente dizível. Esses domínios, que eles mostram de maneiras diferentes mas complementares, são acessados como realidades por formas não discursivas que abrangem as obras de arte, o que Taylor denomina de ‘representações,’ e rituais performativos e restaurativos, tanto pessoais, cívicos e religiosos que incorporam os significados. Dewey e Taylor, divergem, entretanto, sobre se e de que maneira estes domínios precisam transcender a natureza. (shrink)